Scattered throughout the game’s levels are special items for Vince to collect: Zombie Dust Bags, which upon collecting 100 will increase Vince’s health bar; Hearts, which give Vince extra lives; Beads, which are collected from fallen enemies and fill Vince’s voodoo power meter; and Skull Pages, which upon collecting all in a certain level will reveal a Skull. If the player manages to find, chase, and capture the Skull, it will increase the number of voodoo powers Vince can perform at one time. Many levels also offer a trolley station, which allow the player to travel between different levels of the game.
Many of the game’s levels have some sort of puzzle in which Vince must activate some sort of device in order to use it to inflict pain on himself to destroy a larger enemy (the bosses in particular). For instance, in one of the first levels of the game Vince must defeat a pair of unruly gas pumps, by setting himself on fire and then throwing himself in a puddle of gasoline surrounding the gas pumps.
Several levels differ from the standard gameplay the player will experience through the rest of the game and involve piloting a vehicle or playing a minigame. Over the course of the game, the player will control Vince piloting an airplane, a swamp boat, a submarine, a bumper car, and other vehicles.